A PubMed search for Cinnamomum sp. and Type 2 Diabetes using Filters: Humans, Systematic Reviews, Meta-Analysis, English produced 7 results. Most of the results confirmed a modest beneficial effect on FBG but no effect on HbA1c.
A systematic review and meta-analysis not yet indexed in PubMed concluded that the "use of cinnamon showed a beneficial effect on glycaemic control (both HbA1c and FPG) and the short term (<4 months) effects of the use of cinnamon on glycaemic control looks promising." (Cinnamon in glycaemic control: Systematic review and meta analysis. Akilen R, Tsiami A, Devendra D, Robinson N. Clin Nutr. 2012 May 12. [Epub ahead of print] PMID: 22579946)
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Coumarin is present in significant quantities (up to 1%) in cassia cinnamon (Cinnamomum aromaticum). Coumarin has shown hepatotoxic effects in animal models. Although only somewhat dangerous to humans, coumarin is a potent rodenticide: Rats and other rodents metabolize it largely to 3,4-coumarin epoxide, a toxic compound that can cause internal hemorrhage and death. Humans metabolize it largely to 7-hydroxycoumarin, a compound of lower toxicity. [1]
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1. Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers. Abraham K, Pfister M, Wöhrlin F, Lampen A. Mol Nutr Food Res. 2011 Apr;55(4):644-53. Epub 2010 Dec 20. PMID: 21462332
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