Family Medicine Topics

Wednesday, August 22, 2012

Transitioning from IV Infusion to SubQ Insulin in Diabetic Ketoacidosis

PubMed Search
((insulin OR "Insulin"[Mesh]) AND (diabetic ketoacidosis OR "Diabetic Ketoacidosis"[Mesh]) AND (subcutaneous insulin OR "Injections, Subcutaneous"[Mesh]) AND (intravenous insulin OR "Infusions, Intravenous"[MeSH Terms])) AND ( transition* OR guidelines OR guideline OR algorithms OR algorithm OR "Drug Administration Schedule"[MeSH Terms])

Hyperglycemic crises in adult patients with diabetes (Google Scholar)
AE Kitabchi, GE Umpierrez, MB Murphy… - Diabetes …, 2006 - Am Diabetes Assoc ... Hyperglycemic Crises in Adult Patients With Diabetes. ... Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are the two most serious acute metabolic ... 8). Death in these conditions is rarely due to the metabolic complications of hyperglycemia or ketoacidosis ...
Cited by 154 - Related articles - BL Direct - All 23 versions
Above 154 citations narrowed by inclusion of terms: subcutaneous intravenous ketoacidosis insulin transition OR transitional OR transitioning OR guideline OR algorithm OR guidelines OR algorithms

Results: 43 citations

Hyperglycemic crises in adult patients with diabetes (Google Scholar)
AE Kitabchi, GE Umpierrez, MB Murphy… - Diabetes …, 2006 - Am Diabetes Assoc ... Hyperglycemic Crises in Adult Patients With Diabetes. ... Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are the two most serious acute metabolic ... 8). Death in these conditions is rarely due to the metabolic complications of hyperglycemia or ketoacidosis ...
Cited by 154 - Related articles - BL Direct - All 23 versions
Above 154 citations narrowed by inclusion of terms: subcutaneous ketoacidosis insulin OR algorithm OR algorithms
Results: 19 citations

Thursday, August 16, 2012

Gouty Arthritis

Since colchicine is anti-inflammatory is it considered a NSAID? (MeSH)
Colchicine is considered an alkaloid not a NSAID as seen by their classification in the MeSH. Scroll down the MeSH links to view the hierarchical classifications in the MeSH thesaurus.

Gouty Arthritis Reviews (Pubmed)
Limits: English, Humans, Reviews

Timing the Initial Dose of Allopurinol (Pubmed)

Allopurinol and Organ Transplants (Pubmed)

Colchicine and Organ Transplantation (Pubmed)

Wednesday, July 25, 2012

Progestins as an Etiological Factor in Venous Thrombosis

Practice Guidelines (PubMed)

National Guideline Clearinghouse

Comparitive Studies (PubMed)

Meta-Analysis OR Systematic Reviews (PubMed)

Review from Past 5 Years (PubMed)

Progestins & IUD

Progestogens and venous thromboembolism among postmenopausal women using hormone therapy.

In conclusion, progestogens may have differential effects on VTE risk according to the molecules and therefore represent an important potential determinant of the thrombotic risk among postmenopausal women using estrogens. Canonico M, Plu-Bureau G, Scarabin PY. Maturitas. 2011 Dec;70(4):354-60. Epub 2011 Oct 22. Review. PMID: 22024394

Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis
Published data assessing the risk of venous thromboembolism in women prescribed progestin-only contraception are limited. In this meta-analysis of eight observational studies, the use of progestin-only contraception was not associated with an increased risk of venous thromboembolism compared with non-users of hormonal contraception. The potential association between injectable progestins and thrombosis requires further study. Mantha S, Karp R, Raghavan V, Terrin N, Bauer KA, Zwicker JI. BMJ. 2012 Aug 7;345:e4944. PMID: 22872710 [PubMed - in process] PDF

Thursday, July 12, 2012

Cinnamon for Type 2 Diabetes

A PubMed search for Cinnamomum sp. and Type 2 Diabetes using Filters: Humans, Systematic Reviews, Meta-Analysis, English produced 7 results. Most of the results confirmed a modest beneficial effect on FBG but no effect on HbA1c.

A systematic review and meta-analysis not yet indexed in PubMed concluded that the "use of cinnamon showed a beneficial effect on glycaemic control (both HbA1c and FPG) and the short term (<4 months) effects of the use of cinnamon on glycaemic control looks promising." (Cinnamon in glycaemic control: Systematic review and meta analysis. Akilen R, Tsiami A, Devendra D, Robinson N. Clin Nutr. 2012 May 12. [Epub ahead of print] PMID: 22579946)

Current Clinical Trials

Lexicomp

Natural Medicines Comprehensive Database

Coumarin is present in significant quantities (up to 1%) in cassia cinnamon (Cinnamomum aromaticum). Coumarin has shown hepatotoxic effects in animal models. Although only somewhat dangerous to humans, coumarin is a potent rodenticide: Rats and other rodents metabolize it largely to 3,4-coumarin epoxide, a toxic compound that can cause internal hemorrhage and death. Humans metabolize it largely to 7-hydroxycoumarin, a compound of lower toxicity. [1]

The Natural Medicine Comprehensive Database Registration
Then chose first time user and create and account.

1. Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers. Abraham K, Pfister M, Wöhrlin F, Lampen A. Mol Nutr Food Res. 2011 Apr;55(4):644-53. Epub 2010 Dec 20. PMID: 21462332