Progestins as an Etiological Factor in Venous Thrombosis

Practice Guidelines (PubMed)

National Guideline Clearinghouse

Comparitive Studies (PubMed)

Meta-Analysis OR Systematic Reviews (PubMed)

Review from Past 5 Years (PubMed)

Progestins & IUD

Progestogens and venous thromboembolism among postmenopausal women using hormone therapy.

In conclusion, progestogens may have differential effects on VTE risk according to the molecules and therefore represent an important potential determinant of the thrombotic risk among postmenopausal women using estrogens. Canonico M, Plu-Bureau G, Scarabin PY. Maturitas. 2011 Dec;70(4):354-60. Epub 2011 Oct 22. Review. PMID: 22024394

Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis
Published data assessing the risk of venous thromboembolism in women prescribed progestin-only contraception are limited. In this meta-analysis of eight observational studies, the use of progestin-only contraception was not associated with an increased risk of venous thromboembolism compared with non-users of hormonal contraception. The potential association between injectable progestins and thrombosis requires further study. Mantha S, Karp R, Raghavan V, Terrin N, Bauer KA, Zwicker JI. BMJ. 2012 Aug 7;345:e4944. PMID: 22872710 [PubMed - in process] PDF

Cinnamon for Type 2 Diabetes

A PubMed search for Cinnamomum sp. and Type 2 Diabetes using Filters: Humans, Systematic Reviews, Meta-Analysis, English produced 7 results.  Most of the results confirmed a modest beneficial effect on FBG but no effect on HbA1c.

A systematic review and meta-analysis not yet indexed in PubMed concluded that the "use of cinnamon showed a beneficial effect on glycaemic control (both HbA1c and FPG) and the short term (<4 months) effects of the use of cinnamon on glycaemic control looks promising." (Cinnamon in glycaemic control: Systematic review and meta analysis. Akilen R, Tsiami A, Devendra D, Robinson N. Clin Nutr. 2012 May 12. [Epub ahead of print] PMID: 22579946)

Current Clinical Trials

Lexicomp

Natural Medicines Comprehensive Database


Coumarin is present in significant quantities (up to 1%) in  cassia cinnamon (Cinnamomum aromaticum).  Coumarin has shown hepatotoxic effects in animal models.   Although only somewhat dangerous to humans, coumarin is a potent rodenticide: Rats and other rodents metabolize it largely to 3,4-coumarin epoxide, a toxic compound that can cause internal hemorrhage and death. Humans metabolize it largely to 7-hydroxycoumarin, a compound of lower toxicity. [1]


The Natural Medicine Comprehensive Database Registration
Then chose first time user and create and account.  


1. Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers. Abraham K, Pfister M, Wöhrlin F, Lampen A. Mol Nutr Food Res. 2011 Apr;55(4):644-53. Epub 2010 Dec 20. PMID: 21462332