Note:

Best viewed with Internet Explorer

Friday, September 21, 2012

Do Human Lungs and Urinary Bladder Have a Normal Flora?

Hot off the press 09/28/2012:
Identification of microbes in healthy lungs sheds light on cystic fibrosis
Healthy people's lungs are home to a diverse community of microbes that differs markedly from the bacteria found in the lungs of cystic fibrosis patients. That's the result of new research from Stanford University and Lucile Packard Children's Hospital, which has wide implications for treatment of cystic fibrosis and other lung diseases. "The lung is not a sterile organ," said David Cornfield, MD, an author of the new study, which will be published Sept. 26 in Science Translational Medicine. Eurekalert!

Urinary Bladder Metagenome (PubMed)

Wolfe AJ, Toh E, Shibata N, Rong R, Kenton K, Fitzgerald M, Mueller ER, Schreckenberger P, Dong Q, Nelson DE, Brubaker L. J Clin Microbiol. 2012 Apr;50(4):1376-83. Epub 2012 Jan 25. PMID: 22278835 [PubMed - indexed for MEDLINE] Related citations



Lung Metagenome (PubMed)

Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA, Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB. PLoS One. 2011 Feb 22;6(2):e16384. PMID: 21364979 [PubMed - indexed for MEDLINE] Free PMC Article Related citations


Wednesday, September 5, 2012

Rotavirus Vaccines and Incidence of Intussusception


Transient, short segment intussusception
 is frequently seen on abdominal CT's.





Potential Intussusception Risk versus Benefits of Rotavirus Vaccination in the United States.
The burden of severe rotavirus disease averted due to vaccination compared with the vaccine-associated intussusception events offers a side-by-side analysis of the benefits and potential risks. If an intussusception risk similar to that seen internationally exists in the US, it is substantially exceeded by the benefits of rotavirus disease burden averted by vaccination. Desai R, Cortese MM, Meltzer MI, Shankar M, Tate JE, Yen C, Patel MM, Parashar UD. Pediatr Infect Dis J. 2012 Aug 27. [Epub ahead of print] PMID: 22929172